Glycyrrhetinic acid (also called Enoxolon) is derived from the roots of Glycyrrhiza glabra (licorice plant) and is well-known in traditional Chinese medicine. It is a pentacyclic triterpenoid with anti-inflammatory and antimicrobial properties.

Glycyrrhetinic acid helps to preserve the level of hyaluronic acid and elastin against enzymatic degradation by hyaluronidase. Furthermore supports the skin's own repair mechanism against UV-induced DNA damage.